A COMPOSITION-DEPENDENT MOLECULAR CLUTCH BETWEEN T CELL SIGNALING CONDENSATES AND ACTIN

Sweater Vests During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP.These condensates move radially at the IS, traversing successive radially-oriented and concentric actin networks.To understand this movement, we biochemically

Abstract Background With over 230 million surgical procedures performed annually worldwide, better application of evidence in anesthesia and perioperative medicine may reduce widespread variation in clinical practice and improve patient care.However, a comprehensive summary of the complete available evidence has yet to be conducted.This scoping rev